/eGFR (CKD-EPI 2021)

eGFR (CKD-EPI 2021)

Estimates glomerular filtration rate without race

Age
years
Creatinine
mg/dL
Biological Sex

Total Score

0

G5: Kidney failure (ESRD).

90–999+Low
60–89+Moderate
45–59+Moderate
30–44+High
15–29+High
0–14+High

Disclaimer: The clinical scoring and algorithms on this platform are intended strictly for professional informational purposes. They do not constitute a definitive medical diagnosis, treatment, or clinical decision. The final judgment and responsibility lie with the treating physician.

Yasal Uyarı: Bu platformdaki klinik skorlamalar ve algoritmalar yalnızca sağlık profesyonellerini bilgilendirme amaçlıdır. Herhangi bir kesin tıbbi teşhis, tedavi veya klinik karar yerine geçemez. Nihai karar ve sorumluluk hastayı yatak başında değerlendiren hekime aittir.

Clinical Overview

The CKD-EPI 2021 equation estimates Glomerular Filtration Rate (eGFR) based on serum creatinine, age, and sex. This updated guideline explicitly removed the race modifier to eliminate healthcare disparities and is now the globally recommended standard by the NKF and ASN for diagnosing and staging Chronic Kidney Disease (CKD).

Clinical Pearl

While eGFR is excellent for staging stable chronic kidney disease, it is completely invalid in acute kidney injury (AKI) where serum creatinine is rapidly fluctuating. The formula assumes a steady state of creatinine generation and excretion.

Pitfalls & Warnings

  • Invalid in patients with rapidly changing kidney function (AKI).
  • Highly inaccurate in patients with extremes of muscle mass (e.g., bodybuilders, amputees, severe muscle wasting), as creatinine generation deviates heavily from the norm.
  • Not validated for pregnant women.

Academic References

Inker LA, Eneanya ND, Coresh J, et al. New Creatinine- and Cystatin C-Based Equations to Estimate GFR without Race. N Engl J Med. 2021;385(19):1737-1749.

Disclaimer: The clinical scoring and algorithms on this platform are intended strictly for professional informational purposes. They do not constitute a definitive medical diagnosis, treatment, or clinical decision. The final judgment and responsibility lie with the treating physician.