Detects toxic alcohols in serum
Total Score
Normal Osmolar Gap. Toxic alcohol ingestion unlikely.
Disclaimer: The clinical scoring and algorithms on this platform are intended strictly for professional informational purposes. They do not constitute a definitive medical diagnosis, treatment, or clinical decision. The final judgment and responsibility lie with the treating physician.
Yasal Uyarı: Bu platformdaki klinik skorlamalar ve algoritmalar yalnızca sağlık profesyonellerini bilgilendirme amaçlıdır. Herhangi bir kesin tıbbi teşhis, tedavi veya klinik karar yerine geçemez. Nihai karar ve sorumluluk hastayı yatak başında değerlendiren hekime aittir.
The Osmolar Gap is the difference between the measured serum osmolality and the calculated osmolality. An elevated gap (>10 mOsm/kg) in the setting of unexplained metabolic acidosis strongly suggests the presence of unmeasured, osmotically active substances in the blood—most notably toxic alcohols like methanol or ethylene glycol.
In late-presenting toxic alcohol ingestions, the parent alcohol may have already metabolized into toxic acids. At this stage, the Osmolar Gap may actually appear normal while the Anion Gap is severely elevated. Always evaluate both gaps together.
Kraut JA, Mullins ME. Toxic Alcohols. N Engl J Med. 2018;378(3):270-280.
Purssell RA, Pudek M, Brubacher J, Abu-Laban RB. Derivation and validation of a formula to calculate the contribution of ethanol to the osmolal gap. Ann Emerg Med. 2001;38(6):653-659.
Disclaimer: The clinical scoring and algorithms on this platform are intended strictly for professional informational purposes. They do not constitute a definitive medical diagnosis, treatment, or clinical decision. The final judgment and responsibility lie with the treating physician.